Understanding how specific antibodies affect the brain
The Monoclonal Antibody and Reagent Core
This program creates special antibodies and tests them to help understand how certain antibodies might cause brain injury in adults with neuropsychiatric lupus.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11113399 on NIH RePORTER |
What this research studies
This core facility makes and tests specific antibodies and reagents, which are crucial for a larger research program. This program explores how certain antibodies, called DNRAbs, might damage the brain in people with neuropsychiatric lupus (NPSLE). The core ensures these antibodies are produced in large quantities and are of high quality, confirming they bind correctly to their targets. They also help test patient blood samples for these antibodies, providing essential support for the main research projects.
Who could benefit from this research
Good fit: Adults with neuropsychiatric lupus whose blood samples might be used to understand the role of specific antibodies in their condition.
Not a fit: Patients without neuropsychiatric lupus or those not involved in the larger research program would not directly benefit from this core's activities.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how brain injury occurs in neuropsychiatric lupus, potentially guiding new diagnostic tools or treatments.
How similar studies have performed: The specific DNRAbs created by this laboratory are already utilized in various research areas, suggesting a foundation of prior work.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Kowal, Czeslawa Helena — Feinstein Institute for Medical Research
- Study coordinator: Kowal, Czeslawa Helena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.