Understanding how specialized lipids help resolve inflammation in the body
Official title: Characterization Of The Specialized Pro-Resolving Lipid Mediator Metabolome and Implications For Their Endogenous Formation
Funded at Vanderbilt University Medical Center · NIH-11028747 · Data updated 2026-11-12
This study is looking at how certain natural fats in your body can help reduce inflammation, which is important for people dealing with various health issues, and it hopes to find new ways to use these fats, especially alongside medications like aspirin, to improve treatment for inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 5, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $376,250 |
| NIH project number | 1R01GM157599-01 |
| Project ID | NIH-11028747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions, such as atherosclerosis or arthritis.
✕Less likely to help
Patients with acute inflammatory conditions or those not affected by chronic inflammation may not benefit from this research.
What this research studies
This research investigates the role of specialized pro-resolving lipid mediators (SPMs) in controlling inflammation, which is linked to various diseases. By analyzing how these lipids are produced and metabolized in the body, the study aims to uncover their potential therapeutic effects, particularly in relation to drugs like aspirin. The researchers will quantify urinary metabolites of these lipids to better understand their function and effectiveness in promoting inflammation resolution. This could lead to new treatments for inflammatory diseases by harnessing the body's natural mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage inflammation-related diseases.
How similar studies have gone: Previous research has shown promise in understanding lipid mediators in inflammation, but this specific approach to SPM metabolism is relatively novel.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Milne, Ginger Lohr — Vanderbilt University Medical Center
- Study coordinator: Milne, Ginger Lohr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.