Understanding How Special Molecules Affect Blood Stem Cells
Transfer RNAs in Hematopoietic Stem Cell Function
This research looks at how tiny molecules called transfer RNAs help our blood stem cells stay healthy and make all the different blood cells our body needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11145017 on NIH RePORTER |
What this research studies
Our bodies rely on special cells called hematopoietic stem cells, or HSCs, to continuously produce all types of blood cells throughout our lives. When these HSCs don't work correctly, it can lead to serious health issues like anemia or even bone marrow failure, while overactive HSCs can contribute to blood cancers. This project aims to understand how tiny molecules called transfer RNAs (tRNAs) help control the protein-making process within these vital stem cells. By learning how tRNAs influence HSC health and function, we hope to discover new ways to support healthy blood production and prevent blood-related diseases.
Who could benefit from this research
Good fit: This foundational research is relevant to adults experiencing or at risk for blood disorders like anemia and bone marrow failure.
Not a fit: Patients will not receive direct treatment or participate in a clinical trial as part of this foundational laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or treating blood disorders such as anemia and bone marrow failure by improving our understanding of how blood stem cells are regulated.
How similar studies have performed: Previous work by this team has shown similar molecules influence other cell types, but their specific role in blood stem cells is a new area of focus.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ackerman, Susan L — University of California, San Diego
- Study coordinator: Ackerman, Susan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.