Understanding how SOX2 affects glioblastoma cells
Mechanisms of SOX2 Regulation in Glioblastoma
This study is looking at how a protein called SOX2 affects glioblastoma, a tough type of brain cancer, by focusing on special cancer cells that help the tumor grow and resist treatment, with the hope of finding better ways to fight this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10900702 on NIH RePORTER |
What this research studies
This research investigates the role of the SOX2 protein in glioblastoma, a highly aggressive brain tumor. By focusing on a specific group of cancer cells known as glioblastoma stem cells, the study aims to uncover how SOX2 contributes to the tumor's growth and resistance to treatment. The researchers will use advanced techniques, including CRISPR, to manipulate SOX2 and observe the effects on tumor behavior. This could lead to new strategies for targeting these resilient cancer cells and improving treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma, particularly those with treatment-resistant forms of the disease.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that specifically target glioblastoma stem cells, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, suggesting that this approach could yield significant results.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Kim, Albert Hong-Jae — Washington University
- Study coordinator: Kim, Albert Hong-Jae
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.