Understanding how Sonic hedgehog signaling affects cranial neural crest cells
The role of Sonic hedgehog signaling in cranial neural crest potency
This study is looking at how a special signal called Sonic hedgehog helps certain cells in the head develop into important parts like bones and cartilage, which could help us understand and treat facial abnormalities.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11042698 on NIH RePORTER |
What this research studies
This research investigates the role of Sonic hedgehog (Shh) signaling in cranial neural crest cells (CNCCs), which are crucial for forming the craniofacial structure. By examining how Shh influences the differentiation of these cells into various types, including bone and cartilage, the study aims to uncover the mechanisms behind their unique developmental capabilities. The researchers will utilize advanced techniques such as single-cell RNA sequencing and conditional mouse models to analyze the effects of Shh signaling on CNCC potency. This could provide insights into craniofacial abnormalities and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniofacial abnormalities or conditions related to cranial neural crest cell development.
Not a fit: Patients with craniofacial conditions not linked to neural crest cell development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for craniofacial abnormalities.
How similar studies have performed: Previous studies have shown promising results regarding the role of Sonic hedgehog signaling in craniofacial development, indicating that this approach has potential for success.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Han, Simon Joon Young — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Han, Simon Joon Young
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.