Understanding how some people with HIV can maintain viral suppression without treatment
HIV Reservoir Ecology of Viral Remission
This study is looking at people who can keep their HIV under control even after stopping their medication, to understand how they do it and find clues that might help others with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10834304 on NIH RePORTER |
What this research studies
This research investigates the unique characteristics of individuals known as post-treatment controllers (PTCs), who can maintain HIV suppression for extended periods after stopping antiretroviral therapy (ART). By analyzing the viral reservoirs in these individuals, the study aims to uncover the biological mechanisms that allow for this sustained remission. The research involves an international collaboration through the Control of HIV after Antiretroviral Medication Pause (CHAMP) study, which is the largest study of PTCs to date. Participants will undergo detailed virologic assessments to identify potential biomarkers that predict long-term HIV control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been identified as post-treatment controllers, capable of maintaining viral suppression after stopping ART.
Not a fit: Patients who are currently undergoing ART and do not have a history of sustained viral suppression after treatment cessation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that allow more people with HIV to achieve long-term remission without the need for continuous treatment.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of HIV remission, but this study aims to provide deeper insights through a larger and more comprehensive analysis of PTCs.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Li, Jonathan — Brigham and Women's Hospital
- Study coordinator: Li, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.