Understanding how some people resist Alzheimer's disease progression
Genetic resiliency to disease progression in Alzheimer's disease
This study is looking at why some people with Alzheimer's can still think clearly even though they have the disease, by examining special mice and how social interactions might help keep their brains healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11001930 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind why some individuals with Alzheimer's disease (AD) show resilience against cognitive decline despite having the disease's neuropathology. By studying transgenic mice that mimic human AD, researchers aim to identify biological markers associated with resilience, particularly focusing on the expression of ΔFosB in the brain. The study also explores the role of social interaction in reducing dementia risk, which could provide insights into potential therapeutic strategies for patients. Through this approach, the research seeks to uncover factors that help maintain cognitive function in the face of Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who may exhibit varying degrees of cognitive function despite their diagnosis.
Not a fit: Patients with advanced Alzheimer's disease who are already experiencing significant cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous research has shown promise in understanding resilience in Alzheimer's through similar animal models, indicating potential for breakthroughs in human applications.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: St. Romain, Corey — Baylor College of Medicine
- Study coordinator: St. Romain, Corey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.