Understanding how some people resist Alzheimer's disease effects on the brain
Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease Neuropathology
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11052622
This study is looking at why some people can have brain changes linked to Alzheimer's disease but still feel fine, and it’s exploring how certain brain receptors might help protect them from the harmful effects of Alzheimer's proteins.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11052622 on ClinicalTrials.gov |
What this research studies
This research investigates why certain individuals can have significant Alzheimer's disease-related brain changes without showing symptoms. It focuses on the role of specific brain receptors that may protect against the harmful effects of proteins associated with Alzheimer's. By studying these receptors in people who are not demented despite having high levels of Alzheimer's pathology, the research aims to identify potential protective mechanisms. The approach includes analyzing synaptic proteins and their interactions with toxic proteins in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Alzheimer's disease or show signs of Alzheimer's pathology but do not exhibit clinical symptoms.
Not a fit: Patients who are already experiencing significant cognitive decline or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease symptoms in at-risk individuals.
How similar studies have performed: While there has been research on Alzheimer's pathology, this specific investigation into synaptic protection mechanisms in non-demented individuals is relatively novel.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIMON, AGENOR — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: LIMON, AGENOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease