Understanding how some people resist Alzheimer's disease despite brain changes
Synaptic Resilience to Tau in Alzheimer's Disease
['FUNDING_R21'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11137785
This study is looking at why some people can stay sharp and think clearly even when they have signs of Alzheimer's in their brains, and it aims to find out what helps them keep their memory and thinking skills strong, which could lead to new ways to help others with Alzheimer's.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11137785 on ClinicalTrials.gov |
What this research studies
This research investigates why some individuals can maintain cognitive function even when they have high levels of Alzheimer's disease-related brain changes, such as amyloid plaques and tau tangles. The study focuses on the mechanisms that allow these individuals to preserve their synapses, which are crucial for memory and cognitive abilities. By examining brain samples and synaptic health, the researchers aim to uncover factors that contribute to this resilience. This could lead to new strategies for preventing or treating cognitive decline in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who show signs of Alzheimer's disease pathology but do not exhibit dementia symptoms.
Not a fit: Patients who are already experiencing significant cognitive decline or have a diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help protect cognitive function in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding synaptic health in relation to Alzheimer's pathology can provide insights into cognitive resilience, indicating that this approach has potential for success.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERSKOWITZ, JEREMY H. — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: HERSKOWITZ, JEREMY H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.