Understanding how some people naturally control HIV better than others
Characterizing the virologic and immunologic signatures of HIV exceptional control
This study is looking for special people who can keep HIV under control without medication, to learn how they do it and see if their immune systems work differently than those on treatment, which could help improve HIV care and maybe even find a cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10892080 on NIH RePORTER |
What this research studies
This research investigates a unique group of individuals known as exceptional controllers, who can manage HIV infection without antiretroviral therapy. The study aims to identify these individuals and analyze their blood and tissue samples to understand the mechanisms behind their exceptional control of the virus. By comparing them to typical elite controllers and ART-treated individuals, researchers hope to uncover differences in immune response and inflammation levels. This could lead to new insights into HIV management and potential pathways for a cure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who demonstrate exceptional control of the virus without the need for antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who do not exhibit any form of HIV control may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for HIV treatment and possibly a pathway to a cure.
How similar studies have performed: Previous research has shown promise in understanding elite controllers, but the concept of exceptional control is relatively novel and less explored.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Peluso, Michael Joseph — University of California, San Francisco
- Study coordinator: Peluso, Michael Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.