Understanding how some people develop systemic lupus erythematosus from mild autoimmune symptoms.
Mechanisms of New-Onset Autoimmunity/Longitudinal Immune Systems Analysis (MONA-LISA)
['FUNDING_U01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11053509
This study is looking at how some people with mild or no autoimmune symptoms might develop lupus, and it aims to find out what makes them different from those who don’t, so we can create better ways to diagnose and treat the condition.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11053509 on ClinicalTrials.gov |
What this research studies
This research investigates the immunological mechanisms that lead individuals with mild or no symptoms of autoimmunity to develop systemic lupus erythematosus (SLE). By analyzing clinical data and biological samples collected during a previous clinical trial, the study aims to identify differences in immune responses, genetics, and metabolism between those who progress to SLE and those who do not. The goal is to develop better diagnostic tools and potential treatments to prevent the progression of autoimmune conditions, ultimately improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with asymptomatic or minimally symptomatic autoimmunity who may be at risk for developing systemic lupus erythematosus.
Not a fit: Patients with established systemic lupus erythematosus or those without any autoimmune symptoms are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and prevention strategies for individuals at risk of developing systemic lupus erythematosus.
How similar studies have performed: Previous research has shown promise in understanding autoimmune diseases through similar longitudinal analyses, indicating that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARP, DAVID R — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: KARP, DAVID R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.