Understanding how some parasites resist common anti-parasitic drugs
Discovery of Novel Benzimidazole Resistance Mechanisms
This study is looking into how some parasitic worms become resistant to a common anti-parasitic medicine, so we can find better ways to keep these treatments working for people and animals who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10919869 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain parasitic nematodes develop resistance to benzimidazole, a widely used anti-parasitic drug. By utilizing advanced techniques such as CRISPR, the study aims to identify specific genetic changes in these parasites that contribute to resistance. The research focuses on understanding the interactions between the drug and its target in the nematode, as well as the tissues affected by the drug. This knowledge is crucial for developing strategies to combat resistance and ensure the continued effectiveness of anti-parasitic treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in regions where parasitic infections are prevalent and who may be affected by drug-resistant nematodes.
Not a fit: Patients who do not have parasitic infections or who are not at risk of developing drug resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing and preventing drug resistance in parasitic infections, ultimately enhancing treatment outcomes for affected patients.
How similar studies have performed: Previous research has shown success in identifying resistance mechanisms in veterinary medicine, suggesting that similar approaches could be effective in human medicine.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Andersen, Erik Christian — Johns Hopkins University
- Study coordinator: Andersen, Erik Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.