Understanding how some parasites resist a new type of treatment.
Discovery of the mechanisms of resistance for the anthelmintic emodepside
['FUNDING_FELLOWSHIP'] · JOHNS HOPKINS UNIVERSITY · NIH-11051808
This study is looking into why some roundworms can resist a new medicine called emodepside that treats parasitic infections, using tiny roundworms to find out what changes in their genes might make them resistant, so we can find better ways to help people with these infections.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11051808 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind resistance to emodepside, a novel anthelmintic drug used to treat parasitic infections. By utilizing the roundworm Caenorhabditis elegans as a model organism, the study aims to identify the genetic and molecular factors that contribute to resistance against this drug. The research employs advanced techniques such as genome-wide association studies to uncover variations in the worm's genome that may lead to resistance. This knowledge could help develop strategies to combat resistance and improve treatment options for parasitic infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from parasitic nematode infections or those involved in livestock management facing similar issues.
Not a fit: Patients with non-parasitic infections or those not affected by nematode-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for parasitic infections, reducing the burden of these diseases in humans and livestock.
How similar studies have performed: Previous research has successfully identified mechanisms of resistance in other anthelmintic drugs, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAVER, AMANDA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SHAVER, AMANDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.