Understanding how some parasites resist a new type of treatment.
Official title: Discovery of the mechanisms of resistance for the anthelmintic emodepside
Funded at Johns Hopkins University · NIH-11051808 · Data updated 2026-11-12
This study is looking into why some roundworms can resist a new medicine called emodepside that treats parasitic infections, using tiny roundworms to find out what changes in their genes might make them resistant, so we can find better ways to help people with these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 4, 2024 |
| Project end | March 3, 2027 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32AI181342-02 |
| Project ID | NIH-11051808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from parasitic nematode infections or those involved in livestock management facing similar issues.
✕Less likely to help
Patients with non-parasitic infections or those not affected by nematode-related diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms behind resistance to emodepside, a novel anthelmintic drug used to treat parasitic infections. By utilizing the roundworm Caenorhabditis elegans as a model organism, the study aims to identify the genetic and molecular factors that contribute to resistance against this drug. The research employs advanced techniques such as genome-wide association studies to uncover variations in the worm's genome that may lead to resistance. This knowledge could help develop strategies to combat resistance and improve treatment options for parasitic infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for parasitic infections, reducing the burden of these diseases in humans and livestock.
How similar studies have gone: Previous research has successfully identified mechanisms of resistance in other anthelmintic drugs, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Shaver, Amanda — Johns Hopkins University
- Study coordinator: Shaver, Amanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.