Understanding how some mice resist stress-related depression
Official title: Gene Expression Profiling of Stress Resilient Mice within the Nucleus Accumbens
Funded at Icahn School of Medicine at Mount Sinai · NIH-10873084 · Data updated 2026-11-12
This study is looking at how certain genes help mice handle stress better, which could help us understand how to create new treatments for depression in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31MH133297-02 |
| Project ID | NIH-10873084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit are individuals who experience chronic stress but do not develop depression.
✕Less likely to help
Patients who have already been diagnosed with severe depression may not benefit directly from this research.
What this research studies
This research investigates the genetic factors that contribute to stress resilience in mice, particularly focusing on the Nucleus Accumbens, a brain region involved in emotional regulation. By using a model of chronic social defeat stress, the study distinguishes between mice that develop depressive behaviors and those that remain resilient. The goal is to identify specific gene networks that protect against stress-related disorders, which could inform future drug development. Patients may benefit from insights gained about resilience mechanisms that could lead to new treatments for depression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating depression in humans.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to stress resilience, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Gyles, Trevonn Michael — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gyles, Trevonn Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.