Understanding how some individuals resist harmful genetic mutations
Mechanisms of developmental buffering
This study is looking at how some zebrafish can stay healthy even when they have harmful genetic mutations, and it hopes to find out what helps them cope so we can learn more about similar situations in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11041089 on NIH RePORTER |
What this research studies
This research investigates genetic buffering, which is the ability of some individuals to overcome the effects of harmful genetic mutations. Using a zebrafish model, researchers have developed two strains that respond differently to the same genetic mutation, with one strain showing severe defects while the other remains healthy. The study aims to uncover the mechanisms that allow the buffered strain to thrive despite the mutation, focusing on how certain DNA sequences and other factors can restore balance during development. By understanding these processes, the research may provide insights applicable to humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of resilience to such conditions.
Not a fit: Patients with non-genetic health issues or those not affected by genetic mutations may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating the effects of genetic disorders in patients.
How similar studies have performed: Other research has shown promise in understanding genetic buffering mechanisms, but this specific approach using zebrafish is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Nichols, James Tucker — University of Colorado Denver
- Study coordinator: Nichols, James Tucker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.