Understanding how some cancers resist radiation therapy
Acquired Resistance to Therapy and Iron (ARTI) Center
This study is looking into why some lung and esophageal cancers don’t respond well to radiation therapy and hopes to find ways to make these cancers more sensitive to treatment again, helping patients who might be at risk of resistance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917376 on NIH RePORTER |
What this research studies
This research investigates why certain cancers, particularly lung and esophageal cancers, can become resistant to radiation therapy, which is commonly used to treat these conditions. The study focuses on a specific type of cell death called ferroptosis, which may be linked to this resistance. By analyzing patient samples and preclinical models, the researchers aim to identify patients at high risk for developing resistance and explore new treatments that could make cancer cells more sensitive to radiation again. The research involves multiple projects that combine basic science with clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally advanced lung or esophageal cancers who are undergoing radiation therapy.
Not a fit: Patients with cancers that are not locally advanced or those who are not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with lung and esophageal cancers, potentially reducing the risk of cancer recurrence after radiation therapy.
How similar studies have performed: Previous research has shown promising results in understanding cancer resistance mechanisms, but this specific approach focusing on ferroptosis in relation to radiation therapy is relatively novel.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Gan, Boyi — University of Tx Md Anderson Can Ctr
- Study coordinator: Gan, Boyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.