Understanding how somatostatin affects insulin and glucagon release in the pancreas
Mechanisms of Somatostatin-Mediated Inhibition of Insulin and Glucagon
This study is looking at how a hormone called somatostatin affects insulin and glucagon in the pancreas, which could help us understand diabetes better and lead to new ways to manage blood sugar levels for people living with the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10860984 on NIH RePORTER |
What this research studies
This research investigates the role of somatostatin, a hormone that inhibits the secretion of insulin and glucagon from pancreatic cells. By analyzing the signaling mechanisms activated by somatostatin receptors in alpha and beta cells, the study aims to uncover how these processes differ between the two cell types. The research employs transcriptomic analysis to identify key differences in receptor profiles and signaling pathways, which may lead to better understanding of hormone regulation in diabetes. Patients may benefit from insights that could inform new treatments for managing blood sugar levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes mellitus who are interested in new treatment options.
Not a fit: Patients without diabetes or those whose condition is unrelated to insulin or glucagon regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for diabetes management by enhancing our understanding of hormone regulation.
How similar studies have performed: Previous research has shown promise in understanding hormone signaling in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hart, Ryan — University of California at Davis
- Study coordinator: Hart, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.