Understanding how sodium-dependent transporters work in the body
Official title: Dynamics and mechanism of sodium-dependent carboxylate transporters
Funded at New York University School of Medicine · NIH-10991324 · Data updated 2026-11-12
This study is looking at how certain transporters in our body help with fat production and overall health, which could lead to new treatments for metabolic diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 22, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $640,268 |
| NIH project number | 5R01DK135088-03 |
| Project ID | NIH-10991324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders, particularly those related to fatty acid metabolism.
✕Less likely to help
Patients who do not have metabolic disorders or related conditions may not benefit from this research.
What this research studies
This research investigates the sodium-dependent citrate transporter (NaCT) and its bacterial counterpart, VcINDY, which are crucial for fatty acid biosynthesis and metabolic health. The project aims to uncover the molecular mechanisms behind how these transporters function, including their structure and dynamics, by using advanced techniques like cryo-electron microscopy. By identifying how sodium and substrates interact with these transporters, the research seeks to provide insights that could lead to new therapeutic targets for metabolic diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic diseases related to fatty acid biosynthesis.
How similar studies have gone: While there has been significant progress in understanding transporters, this specific approach to studying NaCT and VcINDY is novel and aims to fill existing knowledge gaps.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wang, Daneng — New York University School of Medicine
- Study coordinator: Wang, Daneng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.