Understanding how sodium channels cluster at the neuromuscular junction
Mechanisms of sodium channel clustering at the neuromuscular junction
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11048431
This study is looking into how certain proteins help keep sodium channels organized at the nerve-muscle connection, which is important for muscle strength and preventing fatigue, especially as we age or face muscle disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11048431 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the clustering of sodium channels at the neuromuscular junction, which is crucial for muscle function. By using advanced techniques like proximity biotinylation and CRISPR/Cas9 genome editing, the study aims to identify and validate proteins that play a role in this clustering process. The research focuses on how aging and diseases affect the organization and function of these channels, which are essential for preventing muscle fatigue. Patients may benefit from insights gained about muscle disorders related to sodium channel dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with muscle disorders, particularly those related to aging or specific genetic conditions like muscular dystrophy.
Not a fit: Patients with muscle disorders unrelated to sodium channel dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for muscle disorders that affect movement and strength.
How similar studies have performed: Previous research has shown promising results in understanding neuromuscular junctions, but this specific approach using advanced molecular techniques is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RASBAND, MATTHEW N — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: RASBAND, MATTHEW N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.