NIH-funded research R21 grant

Understanding how social factors affect early-onset colorectal cancer

Official title: Pathways to Prevention: Exploring Social Determinants of Health in Early Onset Colorectal Cancer

Funded at University of Kentucky · NIH-11114847 · Data updated 2026-11-12

This study is looking into why more young people under 50 are getting colorectal cancer and how things like money, education, and access to healthcare might be causing delays in their diagnosis and treatment, especially for Black/African American individuals and those living in rural areas of Kentucky and Georgia, with the goal of finding ways to improve care for everyone affected.

More Colorectal Cancer research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Kentucky
NIH-funded
Lab location1 site (Lexington, United States)
Project startApril 1, 2025
Project endMarch 31, 2027
Funding year2025
Award (this year)$192,610
NIH project number1R21CA301113-01
Project IDNIH-11114847 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals diagnosed with early-onset colorectal cancer, particularly those from Black/African American communities or rural areas.

Less likely to help

Patients diagnosed with colorectal cancer after the age of 50 or those not belonging to the targeted demographic may not benefit from this research.

What this research studies

This research investigates the rising incidence of early-onset colorectal cancer (EOCRC) in individuals under 50, focusing on how social determinants of health (SDoH) such as economic stability, education, and healthcare access influence diagnosis and treatment delays. The study aims to identify disparities in EOCRC outcomes, particularly among Black/African American populations and those in rural areas of Kentucky and Georgia. By analyzing these factors, the research seeks to provide insights that could lead to improved healthcare strategies and interventions for affected individuals.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and improved healthcare strategies for early-onset colorectal cancer, particularly for underserved populations.

How similar studies have gone: Previous research has shown that addressing social determinants of health can significantly impact health outcomes, suggesting potential success for this approach.

Where this research is happening

  • University of Kentucky
    Lexington, United States
    Active

Researchers

  • Principal investigator: Moore, Justin Xavier — University of Kentucky
  • Study coordinator: Moore, Justin Xavier

Related research

Other NIH-funded projects on the same topics.

  • Improving colorectal cancer screening and follow-up care.

    This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.

    NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-9627071

  • Colorectal cancer prognosis through a broad, collaborative study

    A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11590756

  • Ceramides and how they affect metabolism and colorectal cancer in adults

    A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11535283

  • Automated point-of-care DNA methylation test for colorectal cancer in LMICs

    A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11531863

  • Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation

    A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.

    NIH research Yale University · New Haven, United States · NIH-11505210

  • Comparative modeling to guide colorectal cancer screening and care

    A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11495363

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.