Understanding how social connections and rewards affect suicide risk

Transdiagnostic Reward System Dynamics and Social Disconnection in Suicide

['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11038016

This study is looking at how the brain's reward system affects how people with mood or psychotic disorders reach out for help and make safety plans when they're feeling suicidal, with the hope of finding better ways to support them during tough times.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded)
Locations1 site (LA JOLLA, UNITED STATES)
Trial IDNIH-11038016 on ClinicalTrials.gov

What this research studies

This research investigates how the brain's reward system influences social behaviors related to help-seeking and safety planning in individuals at risk for suicide. By focusing on people with affective or psychotic disorders, the study aims to uncover the mechanisms that either promote or hinder social outreach during crises. Participants will be monitored over a year using a combination of lab tasks and real-time assessments to gather data on their experiences and behaviors. The goal is to identify new strategies for improving suicide prevention efforts through better understanding of social dynamics.

Who could benefit from this research

Good fit: Ideal candidates include individuals with affective or psychotic disorders who are currently experiencing suicidal thoughts.

Not a fit: Patients who do not have affective or psychotic disorders or who are not experiencing suicidal ideation may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective suicide prevention interventions by enhancing social support systems.

How similar studies have performed: Previous research has shown promise in understanding the role of social dynamics in mental health, but this specific approach is relatively novel.

Where this research is happening

LA JOLLA, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Affective Disorders

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.