Understanding how social and biological changes affect mental health in adolescent girls

A prospective longitudinal study of transactional associations between social, neural, and hormonal changes and adolescent girls' mental health trajectories

NIH-funded research University of Oregon · NIH-11063812

This study is looking at how friendships and romantic relationships affect the mental health of girls aged 12 to 20, especially during puberty, to help understand who might struggle with anxiety and depression and who might bounce back from these challenges.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Oregon NIH-funded
Lab location1 site (Eugene, United States)
Project IDNIH-11063812 on NIH RePORTER

What this research studies

This research investigates the connections between social relationships, hormonal changes, and mental health in adolescent girls aged 12 to 20. It aims to identify risk and resilience markers for mental health issues, such as anxiety and depression, by examining how friendships and romantic relationships influence these conditions over time. The study will also explore the impact of puberty and brain development on mental health trajectories. By understanding these associations, the research seeks to provide insights into who may experience persistent mental health challenges versus those who may overcome them.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescent girls aged 12 to 20 who may be experiencing or are at risk for mental health issues.

Not a fit: Patients outside the age range of 12 to 20 or those not identifying as female may not receive benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved prevention and intervention strategies for mental health issues in adolescent girls.

How similar studies have performed: Previous research has shown promising results in understanding the links between social relationships and mental health, making this approach both relevant and potentially impactful.

Where this research is happening

Eugene, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.