Understanding how smooth muscle cells affect thoracic aortic disease
Official title: Decreased smooth muscle cell force generation contributes to thoracic aortic disease via altered focal adhesion dynamics, composition, and signaling
Funded at Yale University · NIH-11015431 · Data updated 2026-11-12
This study looks at how certain cells in the aorta change when they work with their surroundings, which could help us understand and find better ways to treat or prevent aortic diseases like aneurysms and dissections.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,300 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heritable thoracic aortic disease or those with genetic predispositions to aortic conditions.
✕Less likely to help
Patients without genetic risk factors for thoracic aortic disease may not benefit from this research.
What this research studies
This research investigates the role of smooth muscle cells in thoracic aortic disease by examining how their ability to generate force is altered. The study focuses on the interactions between these cells and the extracellular matrix, which is crucial for maintaining the structural integrity of the aorta. By analyzing genetic variants that impact these interactions, the research aims to uncover the signaling pathways that lead to conditions like aneurysms and dissections. Patients may benefit from insights that could lead to new treatments or preventive strategies for aortic diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with thoracic aortic disease.
How similar studies have gone: Previous research has shown promising results in understanding the mechanics of smooth muscle cells in relation to aortic diseases, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Milewicz, Dianna M — Yale University
- Study coordinator: Milewicz, Dianna M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.