Understanding how small RNAs silence genes
Structural and Mechanistic basis for RNA Silencing
['FUNDING_OTHER'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11100998
This study is looking at how tiny molecules called small RNAs help control genes and protect our DNA from harmful things, and it's for anyone interested in understanding more about how our bodies work and how this knowledge could help with diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11100998 on ClinicalTrials.gov |
What this research studies
This research investigates the biological processes of RNA silencing, focusing on small RNAs like piRNAs, miRNAs, and siRNAs that play crucial roles in gene regulation. The team will explore the structures and functions of RNA-protein complexes involved in these processes, aiming to uncover how they silence genes and defend the genome against harmful elements. By utilizing advanced techniques in structural biology and biochemistry, the research seeks to fill critical gaps in our understanding of RNA silencing mechanisms, which could have implications for various biological functions and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases influenced by RNA silencing mechanisms.
Not a fit: Patients with conditions unrelated to RNA biology or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic strategies for diseases linked to RNA dysfunction.
How similar studies have performed: Other research has shown promising results in understanding RNA silencing, but this approach aims to provide deeper insights into specific mechanisms that are not yet fully understood.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACRAE, IAN JOHN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: MACRAE, IAN JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.