Understanding how small RNAs silence genes
Structural and Mechanistic basis for RNA Silencing
['FUNDING_OTHER'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10888144
This study is looking at how tiny molecules called small RNAs help control genes and protect our DNA, which could be really helpful for understanding how viruses work and how our bodies defend themselves.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10888144 on ClinicalTrials.gov |
What this research studies
This research investigates the biological processes of RNA silencing, focusing on small RNAs like piRNAs, miRNAs, and siRNAs that play crucial roles in gene regulation. The team will explore the structures and functions of RNA-protein complexes that are essential for the silencing mechanisms, particularly how piRNAs defend the genome and how miRNAs are regulated and utilized by viruses. By employing advanced structural biology and biochemistry techniques, the research aims to fill significant gaps in our understanding of these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to gene expression dysregulation or viral infections.
Not a fit: Patients with conditions unrelated to RNA silencing or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to gene regulation and viral infections.
How similar studies have performed: Previous research has shown promising results in understanding RNA silencing mechanisms, indicating that this approach could yield significant insights.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACRAE, IAN JOHN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: MACRAE, IAN JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.