Understanding how small RNA molecules regulate gene expression
Biogenesis and Function of Regulatory RNAs
This study is looking at tiny RNA molecules that help control how our genes work, using a small worm as a model, to learn more about how these molecules might affect health and diseases, especially when the body is under stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11082471 on NIH RePORTER |
What this research studies
This research investigates the role of non-coding RNAs, particularly microRNAs, in regulating gene expression and their implications for human diseases. Using the model organism Caenorhabditis elegans, the study aims to uncover how these RNA molecules are produced and how they interact with their targets in living systems. By employing advanced biochemical techniques and computational methods, the research seeks to provide insights into the mechanisms of RNA regulation under various conditions, including stress. This work could lead to a deeper understanding of gene regulation and its impact on health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression dysregulation, particularly those with specific cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to RNA regulation or those not affected by gene expression issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to RNA regulation, such as certain cancers.
How similar studies have performed: Previous research has shown promising results in understanding RNA regulation, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Pasquinelli, Amy E. — University of California, San Diego
- Study coordinator: Pasquinelli, Amy E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.