Understanding how small proteins control cell division and development
Spatial and temporal control of Rho family GTPases
This study is looking at how certain proteins help cells divide and shape themselves, using tiny creatures like worms and fruit flies, to better understand what might go wrong in some cancers and birth defects, which could lead to better treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10905997 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that regulate cell division, polarization, and morphogenesis using model organisms like C. elegans and Drosophila. By employing techniques such as live cell imaging, classical genetics, and optogenetics, the study aims to uncover how small GTPases, which are proteins that act at cell membranes, control these critical cellular processes. The findings could provide insights into the underlying causes of certain cancers and birth defects, potentially leading to improved understanding and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or congenital defects linked to cellular dysfunction.
Not a fit: Patients with conditions unrelated to cellular processes or those not affected by cancers or congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cancer and congenital abnormalities, potentially leading to new therapeutic strategies.
How similar studies have performed: Previous research has shown success in understanding cellular processes through similar methodologies, indicating a strong potential for impactful findings.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Glotzer, Michael a. — University of Chicago
- Study coordinator: Glotzer, Michael a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.