Understanding how small molecules control the development of nematodes
Small-molecule signals controlling nematode development
This study is exploring how tiny chemical signals in a small worm called C. elegans affect its growth, metabolism, and behavior, using special techniques to make specific changes in its genes, which could help us understand how these signals impact things like stress and reproduction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10984459 on NIH RePORTER |
What this research studies
This research investigates the role of small-molecule signals in the development, metabolism, and behavior of the nematode Caenorhabditis elegans. By utilizing advanced techniques like CRISPR-Cas9, the researchers aim to create precise mutations in the worm's genome to study how these changes affect the production of important signaling molecules. The project focuses on various classes of signals, including pheromones that influence stress resistance and reproductive development. Through comparative metabolomics, the team will analyze the metabolic changes resulting from these mutations, providing insights into the complex interactions of these signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for potential benefits from this research include individuals involved in agriculture or those affected by parasitic infections.
Not a fit: Patients with conditions unrelated to nematodes or agricultural impacts may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling parasitic nematodes that affect agriculture and human health.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding signaling pathways in other organisms.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Butcher, Rebecca a — University of Florida
- Study coordinator: Butcher, Rebecca a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.