Understanding how small HIV reservoirs affect the ability to stop treatment
Official title: Determining the impact of ultra-small SIV reservoirs on sustained ART-free remission
Funded at University of Wisconsin-Madison · NIH-11015882 · Data updated 2026-11-12
This study is looking at how tiny amounts of HIV that stay in the body might affect the chances of people living with HIV staying healthy without taking their usual medications, and it aims to find out how much these tiny reservoirs need to be lowered to help achieve lasting control of the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 24, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $742,442 |
| NIH project number | 5R01AI174940-03 |
| Project ID | NIH-11015882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on ART and are interested in the possibility of achieving ART-free remission.
✕Less likely to help
Patients who are not living with HIV or those who have advanced HIV/AIDS with significant health complications may not benefit from this research.
What this research studies
This research investigates the relationship between ultra-small HIV reservoirs and the potential for people living with HIV to maintain remission without antiretroviral therapy (ART). By examining the virologic and immunologic factors that influence sustained ART-free remission, the study aims to clarify how much these reservoirs need to be reduced to achieve long-lasting control of the virus. The researchers will utilize mathematical models to predict outcomes after stopping ART, which could help identify effective treatment strategies for HIV. This work is crucial for developing future HIV cure regimens.
Why it matters
Potential benefit: If successful, this research could lead to new strategies that allow individuals with HIV to safely stop ART and maintain viral control.
How similar studies have gone: Previous research has shown promise in understanding HIV reservoirs and their impact on treatment outcomes, but this specific approach is novel and aims to fill critical knowledge gaps.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Reynolds, Matthew R. — University of Wisconsin-Madison
- Study coordinator: Reynolds, Matthew R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.