Understanding how small brain vessel dysfunction affects cognitive health
Diversity Supplement to 1RF1 NS128963
This study is looking at how problems with tiny blood vessels in the brain can affect thinking and memory, especially in conditions like dementia, and it aims to find out how certain brain cells and a specific gene might help us understand and possibly improve treatments for these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10838168 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how dysfunction in small blood vessels in the brain can lead to cognitive impairment and conditions like dementia. By using advanced imaging techniques and mouse models, the study aims to explore the role of specific cell types in the brain's microvasculature and how their loss contributes to serious neurological conditions. The research focuses on the NOTCH3 gene and its impact on vascular health, which could lead to new insights into preventing or treating related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cognitive impairment or those at risk for conditions related to cerebral small vessel disease.
Not a fit: Patients with cognitive impairment due to causes unrelated to small vessel dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline associated with small vessel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of vascular health in cognitive decline, indicating that this approach has potential for success.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Nelson, Mark T — University of Vermont & St Agric College
- Study coordinator: Nelson, Mark T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.