Understanding how small blood vessels in the lungs change in pulmonary hypertension
Anatomic microniches and their contribution to vascular remodeling in pulmonary hypertension
['FUNDING_OTHER'] · MICHAEL E DEBAKEY VA MEDICAL CENTER · NIH-10948106
This study is looking into how certain tiny channels in lung cells might be causing problems in people with pulmonary hypertension, which can lead to heart issues, and it hopes to find new ways to help treat this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHAEL E DEBAKEY VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10948106 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind pulmonary hypertension, a condition that causes the small blood vessels in the lungs to remodel abnormally, leading to heart failure. The study focuses on the role of specific potassium ion channels in vascular smooth muscle cells and how their dysfunction contributes to this remodeling. Conducted at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas, the research will involve collaboration with other institutions to gather comprehensive data. The findings aim to enhance our understanding of pulmonary hypertension and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
Not a fit: Patients with pulmonary hypertension caused by factors unrelated to vascular remodeling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pulmonary hypertension.
How similar studies have performed: Previous research has shown promising results in understanding vascular remodeling in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- MICHAEL E DEBAKEY VA MEDICAL CENTER — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PANDIT, LAVANNYA M. — MICHAEL E DEBAKEY VA MEDICAL CENTER
- Study coordinator: PANDIT, LAVANNYA M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: blood vessel disorder