Understanding how small blood vessel disease affects Alzheimer's disease
Imaging Advancements in Small Vessel and CSF Flow Pathophysiology of Pre-clinical Alzheimer's Disease
This study is looking at how problems with tiny blood vessels in the brain might be related to Alzheimer's disease, using special brain scans to find out more about how these issues work together, with the goal of finding new ways to prevent or treat Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10549382 on NIH RePORTER |
What this research studies
This research investigates the connection between small vessel disease and Alzheimer's disease by exploring how these conditions interact at a molecular level. Using advanced MRI technology, the study aims to identify the mechanisms that link small blood vessel dysfunction and cerebrospinal fluid flow to the development of Alzheimer's. By analyzing brain imaging data, researchers hope to uncover potential targets for prevention and treatment of Alzheimer's disease. This work involves collaboration among multiple institutions to enhance the understanding of these complex relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with signs of small vessel disease.
Not a fit: Patients who do not have any risk factors for Alzheimer's disease or small vessel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting small vessel dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between small vessel disease and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ibrahim, Tamer S — University of Pittsburgh at Pittsburgh
- Study coordinator: Ibrahim, Tamer S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.