Understanding how small airways in the lungs regenerate
Official title: Regulation of distal basal cells in terminal and respiratory airway regeneration
Funded at University of Illinois at Chicago · NIH-10941065 · Data updated 2026-11-12
This study is looking at the tiny airways in your lungs that can get damaged in lung diseases, to better understand their cells and how they work, which could help improve treatments for people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $724,431 |
| NIH project number | 1R01HL174610-01 |
| Project ID | NIH-10941065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic lung diseases, particularly those with damage to the small airways.
✕Less likely to help
Patients with conditions unrelated to small airway damage or those who do not have chronic lung diseases may not benefit from this research.
What this research studies
This research investigates the cellular composition and properties of small airways in the lungs, specifically focusing on terminal and respiratory bronchioles, which are often damaged in lung diseases. By using advanced techniques like single-cell transcriptomics and human stem cell cultures, the study aims to identify novel cell populations and develop new models for understanding small airway biology. The research seeks to fill gaps in knowledge about these regions, which are poorly characterized and crucial for lung health.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for lung diseases affecting small airways, potentially improving patient outcomes.
How similar studies have gone: While research on small airways is limited, preliminary data suggests that similar approaches using human stem cell cultures have shown promise in capturing small airway biology.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kadur Lakshminarasim, Preetish — University of Illinois at Chicago
- Study coordinator: Kadur Lakshminarasim, Preetish
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.