Understanding how SMAD4 affects colorectal cancer
Elucidating the Role of SMAD4 in Colorectal Cancer
This study is looking at how changes in the SMAD4 gene affect colorectal cancer, with the hope of finding new ways to improve treatment and help patients understand their cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10884170 on NIH RePORTER |
What this research studies
This research investigates the role of the SMAD4 gene, a tumor suppressor, in colorectal cancer, which is a leading cause of cancer deaths. The study aims to uncover how mutations in SMAD4 contribute to cancer progression and poor patient outcomes. By examining the molecular mechanisms and pathways involved, particularly the WNT pathway and the serrated tumor pathway, the research seeks to provide insights that could lead to better treatment strategies. Patients may benefit from a deeper understanding of their cancer's genetic profile and potential targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with mutations in the SMAD4 gene.
Not a fit: Patients with colorectal cancer who do not have mutations in the SMAD4 gene may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better prognostic assessments for colorectal cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding the genetic underpinnings of colorectal cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Tong, Kevin — Hackensack University Medical Center
- Study coordinator: Tong, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.