Understanding how slow brain rhythms affect sleep quality
Official title: CRCNS: Mechanisms and consequences of infraslow oscillations in sleep
Funded at University of Pennsylvania · NIH-11192346 · Data updated 2026-11-12
This study is looking at how certain slow brain waves during sleep help us move between different sleep stages, especially from deep sleep to dreaming, and it hopes to find ways to improve sleep quality and health for people with sleep disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $349,965 |
| NIH project number | 5R01AT013188-02 |
| Project ID | NIH-11192346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing sleep disturbances or disorders, particularly those with affective disorders.
✕Less likely to help
Patients without sleep issues or those not affected by chronic conditions related to sleep may not benefit from this research.
What this research studies
This research investigates the role of infraslow oscillations in sleep, focusing on how these rhythms influence the transition between different sleep states, particularly from non-REM to REM sleep. By using a combination of experimental studies and biophysical computational modeling, the research aims to uncover the mechanisms that generate these rhythms and their effects on sleep architecture. Patients may benefit from insights into how these rhythms affect sleep quality and overall health, potentially leading to improved treatments for sleep disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for sleep disorders, enhancing sleep quality for patients.
How similar studies have gone: Other research has shown promising results in understanding brain rhythms and their impact on sleep, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Weber, Franz L — University of Pennsylvania
- Study coordinator: Weber, Franz L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.