Understanding how slow-acting drugs work in the body
Official title: Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug Activity
Funded at State University New York Stony Brook · NIH-10909811 · Data updated 2026-11-12
This study is looking at how the timing of when antibiotics interact with their targets can make them work better against infections, helping to create more effective treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $392,024 |
| NIH project number | 5R35GM149297-02 |
| Project ID | NIH-10909811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from bacterial infections who may benefit from improved antibiotic therapies.
✕Less likely to help
Patients with viral infections or those who do not respond to antibiotic treatments may not benefit from this research.
What this research studies
This research investigates how the timing of drug interactions with their targets affects their effectiveness in treating infections. It focuses on understanding the molecular mechanisms behind slow-onset enzyme inhibition, particularly for antibacterial drugs. By studying how drugs bind and release from their targets over time, the research aims to improve predictions of drug efficacy in real-world conditions. The approach combines structural biology, computational modeling, and enzyme kinetics to develop better drug candidates.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibiotics that work better in patients by improving how we understand drug action over time.
How similar studies have gone: Previous research has shown promise in understanding drug-target interactions, but this specific approach to slow-onset enzyme inhibition is relatively novel.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Tonge, Peter J — State University New York Stony Brook
- Study coordinator: Tonge, Peter J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.