Understanding how slits3 signaling affects fat tissue that generates heat
Official title: Mechanisms of slits3 signaling in thermogenic adipose tissue
Funded at New York University · NIH-11066529 · Data updated 2026-11-12
This study is looking at how a specific signaling process in brown fat helps your body stay warm and burn energy, with the hope of finding new ways to help people manage weight and improve their overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 5, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $527,232 |
| NIH project number | 5R01DK136724-02 |
| Project ID | NIH-11066529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are struggling with obesity or metabolic conditions and are interested in innovative treatment approaches.
✕Less likely to help
Patients who do not have issues related to obesity or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of slits3 signaling in brown adipose tissue (BAT), which is crucial for regulating body temperature and energy expenditure. By analyzing how BAT functions and adapts to cold environments, the study aims to uncover mechanisms that could enhance the body's ability to burn fat and improve metabolic health. The approach includes advanced techniques like single-cell transcriptomic analysis to explore the specific cellular responses within BAT. This research could lead to new strategies for combating obesity and related metabolic diseases.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for obesity and metabolic disorders by enhancing the body's ability to burn fat.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of brown adipose tissue, indicating that this approach has potential for significant advancements.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Shamsi, Farnaz — New York University
- Study coordinator: Shamsi, Farnaz
Related research
Other NIH-funded projects on the same topics.
-
Adolescent girls in Uganda: a long-term look at how money empowerment and family support affect HIV prevention, care, and mental health
A long-term study in rural Uganda will test whether an intervention that combines economic empowerment and family strengthening can help HIV-negative and HIV-affected adolescent girls move safely into young adulthood.
-
Long-term HIV prevention and mental health support for adolescent girls and young women in Uganda
A long-term program in rural Uganda tests if combining economic support and family strengthening helps teenage girls stay HIV-free and improve mental health as they grow into young adults.
-
SNEngage: How Social Networks and Supports Shape Mental Health Care for Black and Latino Individuals with Serious Mental Illness
A long-term study following Black and Latino individuals with serious mental illness to learn how their social networks affect engagement with mental health services and overall well-being.
-
Endosomal signaling and cancer pain control in oral cancer
A study to understand how signals inside nerve cells and supportive cells contribute to pain in people with oral cancer.
-
Accelerating hydroxyurea use for sickle cell disease in Nigeria
A pragmatic study in Nigeria aims to help doctors use hydroxyurea more consistently for people with sickle cell disease.
-
Preventing youth violence by better delivering proven programs to middle schools
A large study in middle schools will test practical ways to help teachers implement a well-known social-emotional learning program so it reaches students as intended.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.