Understanding how SLIT3 affects heart collagen levels
Regulation of Cardiac Collagen Content by SLIT3
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10850942
This study is looking at how a protein called SLIT3 affects collagen in the heart, which is important for understanding heart problems like fibrosis that can make heart failure worse, and it's aimed at finding new ways to help treat these heart issues, especially when the heart is under stress from things like high blood pressure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10850942 on ClinicalTrials.gov |
What this research studies
This research investigates the role of SLIT3, a protein that influences collagen levels in the heart, which is crucial for understanding cardiac fibrosis—a condition that worsens heart failure. The study aims to explore the cellular and molecular mechanisms by which SLIT3 regulates collagen production and cardiac function, particularly under stress conditions like high blood pressure. By using advanced techniques in both laboratory settings and animal models, the researchers hope to uncover new therapeutic targets for treating heart diseases related to fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or related cardiac conditions, particularly those with signs of cardiac fibrosis.
Not a fit: Patients with non-cardiac related health issues or those who do not have any form of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure by targeting collagen regulation, potentially reducing the need for heart transplants.
How similar studies have performed: Previous research has shown promising results in understanding cardiac fibrosis and collagen regulation, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SI, MING-SING — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SI, MING-SING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders