Understanding how sleep quality affects brain health and diseases
Investigating sleep efficiency mechanism and its impact on diseases
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11061888
This study is looking at how sleep quality affects brain health, especially for people at risk of Alzheimer's, by exploring the genes that help some individuals sleep better without harming their health, using mice to find new ways to improve sleep and protect the brain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11061888 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate sleep quality and efficiency, aiming to understand how these factors influence neurological diseases such as Alzheimer's. By studying individuals with a genetic predisposition for short sleep, the team seeks to identify specific genes and pathways that contribute to better sleep efficiency without negative health impacts. The research utilizes mouse models to explore the relationship between sleep and brain health, potentially revealing new targets for treatment. Ultimately, the goal is to enhance our understanding of sleep's role in cognitive function and disease prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those experiencing cognitive decline related to aging.
Not a fit: Patients with sleep disorders unrelated to neurological diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving sleep quality, which may help reduce the risk or severity of neurological diseases.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing sleep efficiency, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FU, YING-HUI — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FU, YING-HUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease