Understanding how sleep problems affect Alzheimer's disease in mice
Official title: Mechanisms of sleep fragmentation in a mouse model of Alzheimer's disease
Funded at Stanford University · NIH-10662118 · Data updated 2026-11-12
This study is looking at how disrupted sleep might affect Alzheimer's disease by using mice to see if certain brain cells play a role, and it will also test if improving sleep can help with thinking skills and slow down the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,902,500 |
| NIH project number | 1RF1AG082202-01 |
| Project ID | NIH-10662118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing sleep disturbances associated with Alzheimer's disease.
✕Less likely to help
Patients with sleep disorders not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between sleep fragmentation and Alzheimer's disease using a mouse model. It aims to explore how changes in sleep patterns, particularly through the activity of specific neurons, may contribute to the progression of Alzheimer's. The study will monitor neuronal activity and assess the impact of amyloid-beta accumulation on sleep architecture. Additionally, it will evaluate whether enhancing sleep through pharmacological or optogenetic methods can improve cognitive function and slow disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sleep quality and cognitive function in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding the link between sleep and Alzheimer's, but this specific approach is novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: De Lecea, Luis — Stanford University
- Study coordinator: De Lecea, Luis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.