NIH-funded research NIH-funded research

Understanding how sleep issues can lead to PTSD after trauma

Official title: Identifying sleep-related risk factors for PTSD and their underlying mechanisms

Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11089450 · Data updated 2026-11-12

This study is looking at how sleep problems after a traumatic event might lead to PTSD, and it's for anyone who has experienced trauma and wants to understand why some people struggle more with sleep than others, so we can find better ways to help them early on.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionHenry Ford Health + Michigan State University Health Sciences
NIH-funded
Lab location1 site (East Lansing, United States)
Project startMay 15, 2024
Project endApril 30, 2028
Funding year2025
Award (this year)$145,142
NIH project number5K23MH134032-02
Project IDNIH-11089450 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals who have recently experienced a traumatic event and are experiencing sleep disturbances.

Less likely to help

Patients who have not experienced trauma or do not have sleep disturbances may not benefit from this research.

What this research studies

This research investigates the connection between sleep disturbances and the development of posttraumatic stress disorder (PTSD) following traumatic events. It aims to identify individuals who are particularly vulnerable to sleep problems after trauma, which could help in targeting early interventions. The study will analyze various biological markers and mechanisms that contribute to this relationship, using advanced data analysis techniques. By understanding these factors, the research seeks to improve prevention strategies for PTSD.

Why it matters

Potential benefit: If successful, this research could lead to better prevention strategies for PTSD by identifying at-risk individuals based on their sleep patterns.

How similar studies have gone: Previous research has shown promising results in understanding the link between sleep disturbances and PTSD, indicating that this approach has potential for success.

Where this research is happening

  • Henry Ford Health + Michigan State University Health Sciences
    East Lansing, United States
    Active

Researchers

  • Principal investigator: Reffi, Anthony — Henry Ford Health + Michigan State University Health Sciences
  • Study coordinator: Reffi, Anthony

Related research

Other NIH-funded projects on the same topics.

  • PTSD and Autoimmune Diseases: How PTSD Might Cause or Change Risk and What Might Help

    This project looks at whether PTSD in Veterans affects the risk of autoimmune diseases and whether there are factors that influence that risk.

    NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11538983

  • Exploring the link between PTSD and autoimmune diseases in veterans.

    This study is looking at how posttraumatic stress disorder (PTSD) might be linked to autoimmune diseases in veterans, especially to help understand the risks and differences among various racial and ethnic groups, with the goal of improving health for those affected.

    NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-10886587

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • ALS risk factors in a long-term ALS study

    A long-term ALS study is looking at which factors may influence disease risk and progression in people living with ALS.

    NIH research Als Therapy Development Foundation · Watertown, United States · NIH-11631679

  • Understanding how work exposures and genes influence ALS risk

    A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11631673

  • Understanding how PTSD affects self-control and brain function

    Researchers are studying how PTSD changes the brain’s control over thoughts and actions, and how this might affect Veterans’ daily lives and responses to treatment.

    NIH research VA Boston Health Care System · Boston, United States · NIH-11617299

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.