Understanding how sleep circuits develop and function in the brain
Development and Function of Sleep Circuits - Extramural Research Programs in the Neurosciences and Neurological Disorders
['FUNDING_R01'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-10833506
This study is looking at how certain genes affect brain development and sleep, especially in people with conditions like autism, to help us understand why some individuals have trouble sleeping.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-10833506 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and molecular mechanisms that connect brain development with sleep regulation throughout life. By using the Drosophila model system, the study aims to identify a specific genetic pathway that is crucial for the development of neurons responsible for sleep regulation. The research will explore how disruptions in this pathway can lead to sleep disturbances, particularly in individuals with neurodevelopmental disorders like autism. The findings could provide insights into the biological basis of sleep-related issues and their impact on overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who experience sleep disturbances, particularly those with neurodevelopmental disorders such as autism.
Not a fit: Patients who do not have sleep disturbances or neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating sleep disturbances associated with neurodevelopmental disorders.
How similar studies have performed: While the specific genetic pathway being studied is novel, previous research has shown that understanding sleep regulation can lead to significant advancements in treating related disorders.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STAVROPOULOS, NICHOLAS — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: STAVROPOULOS, NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome