Understanding how sleep affects epilepsy
Network dynamics of sleep-wake states in epilepsy
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11003725
This study is looking at how sleep affects seizures in people with hard-to-treat epilepsy, using special brain imaging to find out how different brain activities during sleep might help us develop better treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11003725 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between sleep-wake states and epilepsy, particularly focusing on patients who have drug-resistant epilepsy. By using advanced imaging techniques like magnetoencephalography (MEG) and diffusion tensor imaging, the study aims to explore how different brain network dynamics during sleep can influence seizure activity. The goal is to identify specific network features that correlate with varying levels of seizure potential, which could lead to more effective neuromodulation therapies for patients. This approach seeks to provide a mechanistic understanding that could improve treatment outcomes for those suffering from epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with drug-resistant epilepsy who experience frequent seizures despite current treatments.
Not a fit: Patients with well-controlled epilepsy or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more targeted and effective treatments for patients with drug-resistant epilepsy, potentially reducing seizure frequency and improving quality of life.
How similar studies have performed: Previous research has shown promise in understanding the dynamics of brain networks in relation to epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAN, JOLINE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FAN, JOLINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.