Understanding how sleep affects brain recovery after injury
Investigating the role of sleep in synaptic reorganization after neural injury
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10983763
This study is looking at how sleep helps the brain heal after injuries by using fruit flies to see how sleep affects the cleanup of damaged connections in the brain, which could help us understand recovery better for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10983763 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between sleep and the brain's ability to reorganize itself after neural injuries. By studying fruit flies, the researchers aim to uncover how sleep influences the removal of damaged synapses and the overall recovery process. They will explore the signals generated after injuries that promote sleep, the role of glial cells in sleep regulation, and the molecular mechanisms involved in synapse removal during sleep. This could provide valuable insights into how sleep impacts recovery from brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have experienced neural injuries or disorders affecting sleep.
Not a fit: Patients with chronic sleep disorders unrelated to neural injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing recovery from neural injuries by optimizing sleep patterns.
How similar studies have performed: Previous studies have shown that sleep plays a crucial role in brain plasticity and recovery, suggesting that this research builds on established findings.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DONLEA, JEFFREY MICHAEL — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: DONLEA, JEFFREY MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.