Understanding how sleep affects brain health in Alzheimer's disease
Sleep-dependent synaptic homeostasis in Alzheimer's disease
This study is looking at how sleep quality affects memory and thinking in people with early Alzheimer's disease, and it hopes to find ways to improve sleep that could help slow down cognitive decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11078846 on NIH RePORTER |
What this research studies
This research investigates the relationship between sleep quality and cognitive decline in Alzheimer's disease (AD). It aims to understand how disruptions in sleep may contribute to the progression of AD and explores the potential for sleep-based therapies to improve cognitive function. By examining the molecular mechanisms behind sleep's restorative effects on synapses, the study seeks to identify critical windows for intervention that could delay or halt cognitive decline in patients with early-stage AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or those at risk due to age-related cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve sleep quality and, in turn, cognitive function in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of sleep in cognitive health, suggesting that this approach could yield significant insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Diering, Graham Hugh — Univ of North Carolina Chapel Hill
- Study coordinator: Diering, Graham Hugh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.