Understanding how sleep affects brain function and plasticity
Extracting network-level homeostatic rules for sleep/wake states
This study is looking at how sleep affects the brain's ability to adapt and function well, using mice to see if certain brain changes lead to sleep, and it’s designed for anyone curious about the connection between sleep and brain health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10947441 on NIH RePORTER |
What this research studies
This research investigates the relationship between sleep and brain plasticity, aiming to uncover how sleep helps maintain optimal brain function. By developing a machine learning algorithm, the study seeks to predict the mechanisms that govern sleep and neural network stability. Additionally, it will involve continuous monitoring of neuronal activity in mice to explore whether certain levels of brain plasticity trigger sleep. This dual approach combines advanced computational modeling with empirical testing to provide insights into the biological processes underlying sleep.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing sleep disturbances or cognitive issues related to brain plasticity.
Not a fit: Patients with stable sleep patterns and no cognitive impairments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving sleep and brain health, potentially benefiting individuals with sleep disorders or cognitive impairments.
How similar studies have performed: While the relationship between sleep and brain function has been explored, this specific approach utilizing machine learning and continuous neuronal recordings is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Fosque, Leandro Jonathan — Washington University
- Study coordinator: Fosque, Leandro Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.