Understanding how sleep affects brain function and memory.
Official title: CRCNS: Acetylcholine and state-dependent neural network reorganization
Funded at University of Michigan at Ann Arbor · NIH-11080363 · Data updated 2026-11-12
This study looks at how different types of sleep affect our memory and brain function, and it aims to help people understand how better sleep can improve thinking and feelings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 13, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $264,508 |
| NIH project number | 5R01MH135565-03 |
| Project ID | NIH-11080363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing sleep disorders or cognitive impairments, particularly those related to autism spectrum disorders.
✕Less likely to help
Patients without sleep disturbances or cognitive impairments may not receive direct benefits from this research.
What this research studies
This research investigates the critical role of sleep in brain function, particularly focusing on how different sleep states—wake, non-rapid eye movement (NREM), and rapid eye movement (REM)—influence memory consolidation. By examining the dynamics of brain networks during these states, the study aims to uncover how acetylcholine signaling and other mechanisms contribute to the reorganization of brain circuits essential for memory storage. Patients may benefit from insights into how improving sleep could enhance cognitive function and emotional well-being.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive and emotional disorders linked to sleep disturbances.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between sleep and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Zochowski, Michal R — University of Michigan at Ann Arbor
- Study coordinator: Zochowski, Michal R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.