Understanding how skull bone marrow affects recovery after a stroke
Official title: The Skull Bone Marrow Niche After Stroke
Funded at Massachusetts General Hospital · NIH-11045363 · Data updated 2026-11-12
This study is looking at how the bone marrow in your skull helps your brain heal after a stroke by sending special immune cells to fight inflammation, with the hope of finding new ways to improve recovery for stroke patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $798,848 |
| NIH project number | 1R37NS136068-01A1 |
| Project ID | NIH-11045363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a stroke and are experiencing recovery challenges.
✕Less likely to help
Patients who have not had a stroke or those with chronic neurological conditions unrelated to stroke may not benefit from this research.
What this research studies
This research investigates the role of skull bone marrow in the recovery process following a stroke. It focuses on how immune cells, particularly neutrophils, are produced and transported from the skull to the brain during inflammation after a stroke. By examining the connections between the skull marrow and the central nervous system, the study aims to identify potential therapeutic targets to improve stroke recovery. Patients may benefit from insights that could lead to new treatments aimed at regulating inflammation and enhancing healing.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery outcomes for stroke patients by targeting inflammation.
How similar studies have gone: Other research has shown promise in understanding the role of immune cells in stroke recovery, but the specific focus on skull bone marrow is a novel approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Moskowitz, Michael a. — Massachusetts General Hospital
- Study coordinator: Moskowitz, Michael a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.