Understanding how skin proteins affect drug absorption and metabolism
Official title: Quantitative Expression and Inter-Individual Variability of Skin Proteins Involved in Drug and Excipient Metabolism and Transporters Using Targeted and Label Free LC MS/MS Proteomics
Funded at University of Manchester · NIH-10670680 · Data updated 2026-11-12
This study is looking at how certain proteins in your skin help move and break down medications applied to the skin, with the hope of creating better treatments that are personalized for you without needing lots of expensive tests.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Manchester NIH-funded |
| Lab location | 1 site (Manchester, United Kingdom) |
| Project start | September 20, 2021 |
| Project end | September 19, 2025 |
| Funding year | 2023 |
| Award (this year) | $248,810 |
| NIH project number | 5U01FD007348-03 |
| Project ID | NIH-10670680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who use or are prescribed topical medications, particularly those with varying skin conditions.
✕Less likely to help
Patients who do not use topical medications or have no interest in dermatological treatments may not benefit from this research.
What this research studies
This research investigates the role of skin proteins in the metabolism and transport of drugs applied to the skin. By using advanced mass spectrometry techniques, the study aims to quantify key enzymes and transporters in human skin that influence how drugs work. The goal is to develop in silico models that can predict drug behavior without relying heavily on costly clinical trials. This approach could lead to more effective dermatological treatments tailored to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to improved drug formulations that are more effective and safer for patients using topical medications.
How similar studies have gone: Other research has shown promise in using proteomics and in silico models to improve drug formulation, indicating that this approach could be effective.
Where this research is happening
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University of Manchester
Manchester, United Kingdom Active
Researchers
- Principal investigator: Barber, Jill — University of Manchester
- Study coordinator: Barber, Jill
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.