Understanding how skin microbes interact with the body's immune system.
Decoding microbial-Aryl Hydrocarbon Receptor interactions at the skin barrier interface
This study is looking at how the tiny germs on our skin interact with a special protein that helps keep our skin healthy, especially for people dealing with conditions like eczema, acne, and rosacea, to find better ways to protect and treat their skin.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11081214 on NIH RePORTER |
What this research studies
This research investigates the interactions between skin microbes and the aryl hydrocarbon receptor (AHR), which plays a crucial role in maintaining the skin's protective barrier. By exploring how these microbes influence skin health, particularly in conditions like atopic dermatitis, acne, and rosacea, the research aims to uncover mechanisms that could enhance skin barrier function. The study will involve analyzing how environmental factors, such as UV radiation and pollutants, affect these microbial interactions and the skin's response. Patients may benefit from insights that could lead to improved treatments for various skin disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from skin conditions like atopic dermatitis, acne, or rosacea.
Not a fit: Patients with skin conditions unrelated to microbial interactions or those without any skin disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating skin conditions by enhancing the skin's barrier function.
How similar studies have performed: Other research has shown promising results in understanding the role of the microbiome in skin health, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Uberoi, Aayushi — Washington University
- Study coordinator: Uberoi, Aayushi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.